Thermo Fisher Scientific Human Cdc23 Synthetic Peptide

Thermo Fisher Scientific Human Cdc23 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the center of human APC8.
PEP-1063 can be used as a blocking peptide with polyclonal antibody PA5-20949.

Target Information

Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction.
The three classes of enzymes involved in ubiquitination are:

1. Ubiquitin-activating enzymes (E1s)
2. Ubiquitin-conjugating enzymes (E2s)
3. Ubiquitin-protein ligases (E3s)

Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger.
Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins containing destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation.
Mice lacking Ubr2 are infertile due to defects in male meiosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.