Thermo Fisher Scientific PLCG1 Monoclonal Antibody (2B1)
PLCG1 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 단클론 항체. Western blot 및 Immunoprecipitation에 적합. HepG2 세포를 양성 대조군으로 권장. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | View 2 publications |
| Immunoprecipitation (IP) | 1 µg | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B1 |
| Immunogen | Purified, recombinant, human phospholipase C gamma protein expressed in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2163544 |
Product Specific Information
A suggested positive control for this product is HepG2 cells.
Target Information
The mammalian Phospholipase Cγ (PLCγ) family includes two closely related proteins, PLCγ1 and PLCγ2. These isozymes share core structural domains and possess additional domains including a PH domain, two SH2 domains, and one SH3 domain. Upon extracellular stimulation such as hormones or growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCγ. Activated PLCγ catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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