Thermo Fisher Scientific DcR3 Monoclonal Antibody (3C5H10)
Human DcR3 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, Flow cytometry, ELISA 등에 사용 가능. 단백질 G 정제, PBS buffer에 0.05% sodium azide 포함. 연구용으로만 사용.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C5H10 |
| Immunogen | Purified recombinant fragment of human TNFRSF6B (AA: 30–300) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091004 |
Target Information
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family.
A novel DD-containing molecule, designated Daxx (death associated protein 6), binds specifically to the Fas death domain and enhances Fas-induced apoptosis while activating the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues, indicating its important function in Fas signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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