Thermo Fisher Scientific LIGHT Monoclonal Antibody (1D5D10)
인간 및 마우스 반응성의 LIGHT 단클론 항체로 다양한 응용 분야(WB, IHC, Flow, ELISA)에 사용 가능. 정제된 재조합 CD258 단백질을 면역원으로 사용. Protein G로 정제된 액상 형태이며, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D5D10 |
| Immunogen | Purified recombinant fragment of human CD258 (AA: extra 59–240) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093331 |
Target Information
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. It is induced by cytokines such as TNF and Fas ligand through death domain-containing receptors TNFR1 and Fas. These signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Daxx, a DD-containing molecule, binds specifically to the Fas death domain, enhancing Fas-induced apoptosis and activating the JNK pathway. Daxx is widely expressed in fetal and adult human and mouse tissues, indicating its essential role in Fas signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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