Thermo Fisher Scientific CD19 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

CD19 is a member of the immunoglobulin superfamily with two Ig-like domains. It is expressed on 100% of peripheral B cells and may also be present on myeloid leukemia cells, particularly of monocytic lineage. CD19 serves as a key functional regulator of normal and malignant B cell proliferation and is expressed in all B cell precursor leukemias. It acts as a signal-amplifying coreceptor for the B cell receptor (BCR), lowering the threshold for antigen receptor-dependent stimulation. CD19 can also signal independently of BCR co-ligation and functions as a central regulatory component for multiple signaling pathways. Mutations in CD19 can lead to hypogammaglobulinemia, while overexpression causes B cell hyperactivity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.