Thermo Fisher Scientific CDH8 Polyclonal Antibody
인간 CDH8 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200–1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체이며, 뇌 조직 내 신경세포 접착 관련 연구에 적합. 연구용으로만 사용.
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Thermo Fisher Scientific CDH8 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CDH8. Recombinant protein control fragment (Product #RP-90619) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639595 |
Product Specific Information
Immunogen sequence:
TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGIIRLR KPLDFETKKS YTLKVEAANV HIDPRFSGRG PFKDTAT
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 98%
Target Information
CDH8 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, determining the specificity of homophilic cell adhesion activity. Type II (atypical) cadherins lack the HAV cell adhesion recognition sequence specific to type I cadherins. CDH8 is expressed in the brain and is involved in synaptic adhesion, axon outgrowth, and guidance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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