Thermo Fisher Scientific SMCR8 Polyclonal Antibody
SMCR8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 1 mg/mL 농도의 액상 형태입니다. 자가포식 및 mTORC1 신호 조절 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600 to 650 of Human Smith-Magenis Syndrome Chromosome Region, Candidate 8 (SMCR8) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
SMCR8 is a component of the C9orf72–SMCR8 complex, which exhibits guanine nucleotide exchange factor (GEF) activity and regulates autophagy.
Within this complex, C9orf72 and SMCR8 act as catalytic subunits that promote the exchange of GDP to GTP, activating RAB8A and RAB39B, and facilitating autophagosome maturation.
The complex also negatively regulates autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its activity.
Additionally, SMCR8 regulates mTORC1 signaling by promoting phosphorylation of its substrates and also localizes to the nucleus, where it associates with chromatin and represses expression of ULK1 and WIPI2 genes.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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