Thermo Fisher Scientific SMCR8 Polyclonal Antibody
SMCR8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며 4°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600 to 650 of Human Smith-Magenis Syndrome Chromosome Region, Candidate 8 (SMCR8, UniProt ID: Q8TEV9-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
SMCR8 is a component of the C9orf72–SMCR8 complex, which exhibits guanine nucleotide exchange factor (GEF) activity and regulates autophagy. Within the complex, C9orf72 and SMCR8 likely serve as catalytic subunits that facilitate the exchange of GDP to GTP, activating RAB8A and RAB39B to promote autophagosome maturation.
Additionally, the complex negatively regulates autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its kinase activity.
SMCR8 also modulates mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. Beyond its cytoplasmic role, SMCR8 localizes to the nucleus, associates with chromatin, and downregulates expression of ULK1 and WIPI2 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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