Thermo Fisher Scientific SPDL1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
LQIATLLQMK GSQTEFEQQE RLLAMLEQKN GEIKHLLGEI RNLEKFKNLY DSMESKPSVD SGTLEDNTYY TDLLQMKLDN LNKEIESTKG ELS

Highest antigen sequence identity to the following orthologs:

• Mouse: 77%
• Rat: 79%

Target Information

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and suprabasal layers). The protein was found mainly in stratified squamous epithelium. It is moderately repressed by retinoic acid. The antigen localized to basal keratinocytes, although it was also found at lower levels in the suprabasal layers, where it concentrated to areas of cell-to-cell contact. The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell-cell and/or cell-matrix interactions necessary for normal growth control.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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