Thermo Fisher Scientific IA-1 Polyclonal Antibody
IA-1 (INSM1) 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화됨. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 포맷. 냉장 보관(2–8°C) 가능하며 장기 보관 시 -20°C 권장.
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Applications
- Western Blot (WB): Tested dilution 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide from near the amino terminus of human IA-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | 2–8°C (up to 3 months), -20°C (long term) |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153293 |
Product Specific Information
- Suggested positive control: rat thymus tissue lysate
- Can be used with blocking peptide PEP-0937
Target Information
IA-1 (also known as INSM1) is a zinc-finger transcription factor initially identified from an insulinoma cDNA library and expressed in the developing nervous system. It is present in the forebrain, midbrain, hindbrain, spinal cord, retina, and olfactory bulb as early as embryonic day 9.5 in mice. IA-1 functions as a transcriptional repressor and participates in several signaling pathways, including Notch, sonic hedgehog, and Ngn3 during pancreatic endocrine cell differentiation. It is expressed in multiple neuroendocrine tumors and nearly all small cell lung carcinomas, making it a potential target in cancer research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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