Thermo Fisher Scientific RUSC1 Polyclonal Antibody
Thermo Fisher Scientific의 RUSC1 Polyclonal Antibody는 Human, Mouse, Rat에 반응하며 Western blot에 적합합니다. Rabbit IgG 기반의 비결합형 액상 항체로, 항원 친화 크로마토그래피로 정제되었습니다. RUSC1 단백질 연구용으로 사용되며, NF-kappa-B 신호전달 관련 연구에 유용합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide from near the carboxy terminus of human RUSC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154304 |
Product Specific Information
- Suggested positive control: A-20 cell lysate
- Can be used with blocking peptide PEP-0936
Target Information
RUSC1 (also known as NESCA) shares with the related protein RUSC2 a common domain structure including RUN, leucine zipper, and SH3 domain, with over 30% amino acid identity.
RUSC1 is an adapter protein that binds to the TrkA receptor and is necessary for NGF-induced neurite growth in PC12 cells.
It interacts with IKK-γ (regulatory subunit of the IKK complex) required for NF-kappa-B activation in signaling pathways such as TNF-R or TLR.
RUSC1 also binds to the E3 ubiquitin ligase TRAF6, which catalyzes RUSC1 polyubiquitination. Overexpression of RUSC1 inhibits TRAF6-mediated polyubiquitination of IKK-γ, suggesting RUSC1 may link IKK-γ-mediated NF-kappa-B activation.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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