Thermo Fisher Scientific Complement C5 Polyclonal Antibody
Thermo Fisher Scientific의 Complement C5 Polyclonal Antibody는 인간 및 랫트 반응성을 가지며 Western blot, ELISA, ICC/IF에 적용 가능합니다. Recombinant C5/C5a 단백질을 면역원으로 사용한 고품질 rabbit IgG 항체로, 액상 형태로 제공되며 -20°C에서 보관합니다.
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Thermo Fisher Scientific Complement C5 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| ELISA | 1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Not Applicable |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1567–1676 of human C5/C5a (NP_001726.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.42 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2808735 |
Product Specific Information
Immunogen sequence:
SITVENVFVK YKATLLDIYK TGEAVAEKDS EITFIKKVTC TNAELVKGRQ YLIMGKEALQ IKYNFSFRYI YPLDSLTWIE YWPRDTTCSS CQAFLANLDE FAEDIFLNGC
Positive Samples:
U-937, Raji, Jurkat, Mouse heart, Rat liver
Target Information
C5 (Complement C5) is a protein-coding gene. Diseases associated with C5 include Complement Component 5 Deficiency and Eculizumab Poor Response.
Related pathways include GPCR downstream signalling and Acquired partial lipodystrophy (Barraquer-Simons syndrome).
Gene Ontology (GO) annotations: signaling receptor binding and endopeptidase inhibitor activity.
A paralog of this gene is C3.
C5 encodes a component of the complement system, part of the innate immune system essential for inflammation, homeostasis, and defense against pathogens.
The encoded preproprotein is processed into multiple products, including C5 alpha chain, C5 beta chain, C5a anaphylatoxin, and C5b.
C5a functions as a potent spasmogenic and chemotactic factor, while C5b contributes to the formation of the membrane attack complex (MAC).
Mutations in this gene lead to complement component 5 deficiency, resulting in recurrent bacterial infections.
Alternative splicing yields multiple transcript variants.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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