Thermo Fisher Scientific PFKFB3 Polyclonal Antibody
PFKFB3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP에 사용 가능하며, 인간 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로, 연구용으로만 사용.
- 카탈로그번호
- PA521931
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 457–520 (Q16875) of PFKFB3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.95 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153160 |
Product Specific Information
- Recommended positive controls: A431, H1299
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The PFKFB3 gene encodes a bifunctional enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a key regulator of glycolysis in eukaryotic cells.
This enzyme exhibits 6-phosphofructo-2-kinase activity (synthesis of F2,6BP) and fructose-2,6-bisphosphatase activity (degradation of F2,6BP).
PFKFB3 is essential for cell cycle progression and prevention of apoptosis, acting as a regulator of cyclin-dependent kinase 1 and linking glucose metabolism to cell proliferation and survival in tumor cells.
Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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