Thermo Fisher Scientific CTNNB1 Monoclonal Antibody (4F2)
CTNNB1 단백질을 인식하는 Mouse monoclonal antibody (Clone 4F2)로, Human 시료에 반응합니다. Western blot 및 ELISA에 사용 가능하며, Affinity chromatography로 정제된 액상 형태입니다. Beta-catenin 관련 세포 부착 및 신호전달 연구에 적합합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CTNNB1 Monoclonal Antibody (4F2)
Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F2 |
| Immunogen | CTNNB1 (AAH58926, 682–781 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LFRTEPMAWN ETADLGLDIG AQGEPLGYRQ DDPSYRSFHS GGYGQDALGM DPMMEHEMGG HHPGADYPVD GLPDLGHAQD LMDGLPPGDS NQLAWFDTDL
Target Information
Beta-catenin, an adherens junction (AJ) protein, is a key component of cell-cell adhesion structures. It interacts with the cytoplasmic domain of E-cadherin, linking it to alpha-catenin and the cortical actin cytoskeleton. Beta-catenin also associates with complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways such as Wnt/Wingless.
Its regulation of morphogenesis and cell proliferation is crucial in epithelial maintenance and tumorigenesis. Aberrant expression has been implicated in pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting transcription of genes like cyclin D and c-myc.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.