Thermo Fisher Scientific ASL Polyclonal Antibody
ASL 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제. -20°C 보관, 동결/해동 반복 피해야 함.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 289–464 of human ASL (NP_000039.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.84 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914564 |
Product Specific Information
Positive test controls include: HeLa, HepG2, SH-SY5Y, Mouse liver, Mouse brain, Mouse kidney, Rat liver.
Immunogen sequence:
NPDSLELIRS KAGRVFGRCA GLLMTLKGLP STYNKDLQED KEAVFEVSDT MSAVLQVATG VISTLQIHQE NMGQALSPDM LATDLAYYLV RKGMPFRQAH EASGKAVFMA ETKGVALNQL SLQELQTISP LFSGDVICVW DYGHSVEQYG ALGGTARSSV DWQIRQVRAL LQAQQA
Target Information
ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle.
Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria (argininosuccinic acid lyase deficiency).
A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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