Thermo Fisher Scientific CD230 (PrP) Monoclonal Antibody (ROS-BC6)
양 CD230(PrP) 단백질을 인식하는 Thermo Fisher의 단클론 항체로, Western blot, IHC, Flow cytometry 등 다양한 응용에 적합. 단백질 G로 정제된 액상 항체이며, 1 mg/mL 농도로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Sheep |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ROS-BC6 |
| Immunogen | A truncated form of recombinant Ovine PRP spanning residues aa94–aa233 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | <0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745289 |
Product Specific Information
Mouse anti-Sheep CD230 (PrPsc) antibody, clone ROS-BC6 recognizes the prion disease form of prion protein known as CD230.
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associated with lipid raft components and functioning as a signaling molecule.
PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in the distribution of junction-associated proteins in human enterocytes.
Conversion of the normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step triggering the pathogenesis of prion neurodegenerative disorders such as Creutzfeldt-Jakob disease (CJD).
Whereas PrPc is rich in alpha-helices, the PrPSc form has higher beta-sheet content and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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