Thermo Fisher Scientific CD21 Monoclonal Antibody (CC51), PE
Thermo Fisher CD21 단클론 항체(CC51)는 소 CD21 항원을 인식하며 PE 형광체로 결합된 Flow Cytometry용 항체입니다. 단클론 Mouse IgG2b 형이며 Protein A로 정제되었습니다. 4°C 보관, 재구성 후 사용. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CC51 |
| Immunogen | Bovine (Friesian cattle) mesenteric lymph node cells |
| Conjugate | PE (Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 5% sucrose, 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745285 |
Additional Formats
Product Specific Information
Mouse anti-Bovine CD21 monoclonal antibody, clone CC51, recognizes the bovine homologue of the human CD21 cell surface antigen, a 145 kDa single-pass type I membrane glycoprotein containing multiple sushi domains.
Reconstitution: Add 1.0 mL distilled water.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen.
CD21 plays key roles in:
- Uptake and retention of immunocomplexes
- Survival of memory B cells
- Development and maintenance of the humoral response to T-dependent antigens
It also serves as a receptor for Epstein-Barr virus and is involved in prion targeting to follicular dendritic cells.
Soluble CD21 (sCD21) retains ligand-binding ability.
CD21 interacts with CD23, CD19, CD81, and Leu13 to form a signal-transduction complex involved in B cell activation.
Genetic variations in CD21 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternatively spliced transcript variants encoding different isoforms of CD21 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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