Thermo Fisher Scientific CD21 Monoclonal Antibody (CC51), PE

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Additional Formats

• Unconjugated
• FITC
• Request custom conjugation

Product Specific Information

Mouse anti-Bovine CD21 monoclonal antibody, clone CC51, recognizes the bovine homologue of the human CD21 cell surface antigen, a 145 kDa single-pass type I membrane glycoprotein containing multiple sushi domains.
Reconstitution: Add 1.0 mL distilled water.

Target Information

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen.
CD21 plays key roles in:

• Uptake and retention of immunocomplexes
• Survival of memory B cells
• Development and maintenance of the humoral response to T-dependent antigens
  It also serves as a receptor for Epstein-Barr virus and is involved in prion targeting to follicular dendritic cells.
  Soluble CD21 (sCD21) retains ligand-binding ability.
  CD21 interacts with CD23, CD19, CD81, and Leu13 to form a signal-transduction complex involved in B cell activation.
  Genetic variations in CD21 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
  Alternatively spliced transcript variants encoding different isoforms of CD21 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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