Thermo Fisher Scientific Ly-49C/I/F/H Monoclonal Antibody (14B11), PE, eBioscience

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 0.125 µg/test
  View 6 publications

Product Specifications

Additional Formats

• Biotin
• FITC
• Request custom conjugation

Product Specific Information

The 14B11 monoclonal antibody reacts with a subset of mouse Ly-49 receptors and recognizes a majority of mouse NK cells. This antibody binds to three putative inhibitory members of the Ly-49 family (F, I, and C) and one activating receptor, Ly-49H. 14B11 does not react with Ly-49A, B, D, or G. It has been reported to enhance the redirected lysis of FcR⁺ target cells by IL-2-activated NK cells.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Tested on mouse splenocytes at ≤0.125 µg/test (100 µL final volume). Cell number should be empirically determined (10⁵–10⁸ cells/test).
• Excitation: 488–561 nm
• Emission: 578 nm
• Laser Compatibility: Blue, Green, Yellow-Green Lasers
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

KLRA3 (Ly49C) is a member of the LY49 receptor family in Natural Killer (NK) cells that bind to MHC class I molecules. These receptors are classified as activating or inhibitory based on the presence of ITIM (inhibitory) or ITAM (activating) motifs. KLRA3 is considered an inhibitory receptor recognizing peptide-receptive H-2Kb.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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