Thermo Fisher Scientific CD9 Monoclonal Antibody (eBioSN4 (SN4 C3-3A2)), APC, eBioscience
인간 CD9 단백질을 인식하는 eBioSN4 클론의 마우스 단클론 항체로, APC 형광체 결합형입니다. Flow cytometry에 최적화되어 있으며, 5 µL/test로 사용 가능합니다. 세포 부착, 이동, 신호전달 연구에 적합하며 암세포 전이 억제 관련 연구에 활용됩니다.
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Thermo Fisher Scientific CD9 Monoclonal Antibody (eBioSN4 (SN4 C3-3A2)), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test | View 4 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioSN4 (SN4 C3-3A2) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2762436 |
Available Formats
- Unconjugated
- Biotin
- FITC
- PE
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 645
- Custom conjugation available upon request
Product Specific Information
The eBioSN4 monoclonal antibody reacts with human CD9, a 24 kDa member of the tetraspanin family with four hydrophobic transmembrane domains. CD9 is expressed in platelets, eosinophils, basophils, pre-B cells, activated T cells, and neural cell lines. It is associated with malignant phenotypes, being expressed on most non-T cell acute lymphoblastic leukemia cells and on many chronic lymphocytic and acute myeloblastic leukemia cells.
In platelets, CD9 is localized in alpha-granules and associates with integrin αIIb/βIII, playing a role in platelet aggregation. CD9 also induces aggregation of pre-B cell lines and promotes adhesion and migration of pre-B and Schwann cells. It provides a co-stimulatory signal for T cells independently of CD28. The eBioSN4 antibody partially cross-blocks binding of another anti-human CD9 monoclonal antibody, MM2/57.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested by flow cytometry using normal human platelets. Recommended use: 5 µL (0.25 µg) per test (final volume 100 µL).
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Target Information
CD9 antigen is a glycoprotein expressed on developing B lymphocytes, platelets, monocytes, eosinophils, basophils, stimulated T lymphocytes, neurons, and glial cells. It belongs to the tetraspanin family with four transmembrane domains. CD9 regulates cell activation and aggregation, possibly through association with integrin CD41/CD61 (GPIIb/GPIIIa). It is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, sperm-egg fusion, and plays roles in cell attachment, proliferation, and immune cell signaling. CD9 expression is critical in suppressing cancer cell motility and metastasis, acting as a metastasis suppressor in solid tumors.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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