Thermo Fisher Scientific CD81 Polyclonal Antibody
CD81 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 0.5–1 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC-F) | 0.5–1 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL | - |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells | - |
| ELISA | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human TAPA1 recombinant protein (Position: F113–K201) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2746119 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family expressed on most nucleated cells, especially germinal center B cells. It forms complexes with other tetraspanins, integrins, coreceptors, and MHC molecules, influencing cell adhesion, activation, proliferation, and differentiation of B and T cells.
In muscle tissue, CD81 promotes cell fusion and myotube maintenance. It also functions as a receptor for the hepatitis C virus (HCV). Like other tetraspanins (CD9, CD37, CD53, CD63, CD82), CD81 is a cell-surface glycoprotein characterized by four hydrophobic domains and involved in signal transduction regulating cell development and motility.
CD81 associates with CD19, CD21, Leu 13, and integrins on the cell membrane and may play a role in tumor suppression. Antibodies to CD81 exhibit anti-proliferative effects on certain lymphoid cell lines, particularly large cell lymphomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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