Thermo Fisher Scientific Phospho-FGFR1 (Tyr766) Polyclonal Antibody
FGFR1 Tyr766 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. IHC(P) 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되어 순도 95% 이상입니다. 1 mg/mL 농도의 액상 제품으로 연구용으로 사용됩니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyrosine 766 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553703 |
Product Specific Information
- Detects endogenous FGFR1 protein at a molecular weight of approximately 140 kDa.
- Purity >95% by SDS-PAGE.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor (FGFR) family, comprising four membrane-spanning tyrosine kinases (FGFR1–4) that serve as high-affinity receptors for 17 growth factors (FGF1–17).
FGFR1 is involved in various biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
Alternative splicing generates multiple FGFR1 variants expressed differently during embryonic development and in adult tissues.
Mutations or defects in FGFR1 are associated with multiple disorders including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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