Thermo Fisher Scientific Phospho-FGFR1 (Tyr766) Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

• Detects endogenous FGFR1 protein at a molecular weight of approximately 140 kDa.
• Purity >95% by SDS-PAGE.

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor (FGFR) family, comprising four membrane-spanning tyrosine kinases (FGFR1–4) that serve as high-affinity receptors for 17 growth factors (FGF1–17).
FGFR1 is involved in various biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
Alternative splicing generates multiple FGFR1 variants expressed differently during embryonic development and in adult tissues.
Mutations or defects in FGFR1 are associated with multiple disorders including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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