Thermo Fisher Scientific c-Met Polyclonal Antibody
개 및 c-Met 단백질에 특이적인 Goat Polyclonal Antibody. Western blot, ELISA, 중화 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며 방부제 무첨가. -20°C 보관, 재구성 후 0.2 mg/mL 농도로 사용 가능.
- 카탈로그번호
- PA547585
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| ELISA (Detection) | 0.1–0.4 µg/mL |
| ELISA (Capture) | 0.2–0.8 µg/mL |
| Neutralization (Neu) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant canine HGF R/c-MET (Glu25–Leu935) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607127 |
Product Specific Information
- In sandwich ELISAs, less than 0.2% cross-reactivity with recombinant human HGF R and recombinant mouse HGF R is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
MET (c-MET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET plays a critical role in embryonic development including gastrulation, muscle and neuron formation, angiogenesis, and kidney development. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling.
MET dysregulation has been associated with several cancers including gastric, renal, and breast cancers, making it a key target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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