Thermo Fisher Scientific Phospho-p70 S6 Kinase (Ser418) Polyclonal Antibody
Phospho-p70 S6 Kinase (Ser418) 폴리클로날 항체로 인간, 생쥐, 랫트 반응성. Western blot, IHC, ICC/IF, ELISA에 적합. 항원 친화 크로마토그래피 정제, 고농도 액상 형태. 세포 성장 및 단백질 합성 연구용.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| ELISA | 1:20,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human p70 S6 kinase alpha around the phosphorylation site of S418 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609154 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical catalytic domains that phosphorylate several residues of the S6 ribosomal protein. It is predominantly localized in the cytoplasm and plays a crucial role in growth factor-regulated cell proliferation, cell motility, immune response, and tissue repair. Acting downstream of phosphoinositide (PI) 3-kinase, its main physiological target is the S6 ribosomal protein, which promotes protein synthesis and cell proliferation. Amplification and overexpression of p70 S6 kinase are observed in certain breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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