Thermo Fisher Scientific NMDAR3A Polyclonal Antibody
Rabbit polyclonal antibody targeting human NMDAR3A. Validated for WB and IHC (Paraffin). Lyophilized form for stable storage. Suitable for research on NMDA receptor function and signaling mechanisms.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 980–1030 of human NMDAR3A conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of MQ water. Centrifuge to remove any insoluble material.
Specificity: NMDAR3A.
Target Information
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels characterized by reduced single-channel conductance, low calcium permeability, and low voltage-dependent sensitivity to magnesium. It is glycine-mediated and may play roles in dendritic spine development and PPP2CB-NMDAR signaling. Grin3a belongs to the glutamate-regulated ion channel superfamily, functioning in physiological and pathological processes of the central nervous system. It shares >90% identity with the rat subunit. Knockout mouse studies suggest involvement in synaptic development via modulation of NMDA receptor activity.
Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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