Thermo Fisher Scientific NMDAR3A Polyclonal Antibody
NMDAR3A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 IHC(P) 검증 완료. 쥐와 생쥐에서 반응하며, 신경세포 수용체 연구에 적합. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 800–850 of extracellular domain of rat NMDAR3A conjugated to blue carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and shares 95% identity with human sequence.
- Specificity: NMDAR3A.
Target Information
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability, and low voltage-dependent sensitivity to magnesium.
It is mediated by glycine and may play a role in the development of dendritic spines and PPP2CB-NMDAR mediated signaling mechanisms.
Grin3a belongs to the superfamily of glutamate-regulated ion channels, functioning in physiological and pathological processes in the central nervous system.
Grin3a shows greater than 90% identity to the corresponding subunit in rat.
Studies in knockout mice deficient in Grin3a suggest involvement in synaptic element development by modulating NMDA receptor activity.
Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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