Thermo Fisher Scientific Cofilin 1 Polyclonal Antibody
Cofilin-1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 사용 가능. 인간, 마우스, 랫트에 반응하며 비결합형 상태로 제공. 세포골격 조절 연구 및 세포 형태 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal part of human Cofilin-1 (Cofilin, non-muscle isoform) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water and centrifuge to remove any insoluble material.
- The antigen is homologous in rat and mouse.
- Specificity: Cofilin-1.
Target Information
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. It regulates actin cytoskeleton dynamics and is essential for normal mitosis and cytokinesis. Cofilin plays a key role in maintaining cell morphology and cytoskeletal organization, and is required for the regulation of atypical chemokine receptor ACKR2 trafficking to the cell membrane, enhancing chemokine uptake and degradation. It is also necessary for neural tube morphogenesis and neural crest cell migration.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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