Thermo Fisher Scientific RARA Monoclonal Antibody (OTI7B8), TrueMAB
Human RARA 단백질(aa 52-299)을 인식하는 Mouse IgG1 단클론 항체로 Western blot에 적합. 액상 형태이며 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보존. -20°C에서 보관하며 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific RARA Monoclonal Antibody (OTI7B8), TrueMAB
Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 52–299 of human RARA produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to ligands such as all-trans or 9-cis retinoic acid, regulating gene expression in various biological processes. The RXR/RAR heterodimers bind to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites (DR1–DR5).
In the absence of ligand, RXR-RAR heterodimers associate with transcription corepressors inducing histone acetylation, chromatin condensation, and transcriptional suppression. Upon ligand binding, corepressors dissociate and coactivators are recruited, leading to transcriptional activation.
RARA plays an essential role in retinoic acid-induced germ cell development during spermatogenesis, supporting survival of early spermatocytes and promoting meiotic progression. In combination with RARG, it is required for skeletal growth, matrix homeostasis, and growth plate function. RARA regulates gene expression via ligand-dependent recruitment of chromatin complexes containing KMT2E/MLL5 and mediates retinoic acid-induced granulopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.