Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (OTI1C4), TrueMAB
Human TNFRSF18(GITR) 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot에 최적화됨. TrueMAB 형식으로 제공되며, 고순도 Affinity chromatography로 정제됨. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 26–162 of human TNFRSF18 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR, is encoded by the TNFRSF18 gene in humans and mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The receptor shows increased expression upon T-cell activation and plays a key role in immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice suggest its role in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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