Thermo Fisher Scientific PDCD5 Polyclonal Antibody
PDCD5 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 세포 사멸 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human PDCD5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2720921 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Programmed cell death 5 (PDCD5) is a human apoptosis-related protein that plays an early and universal role in apoptosis. It is widely expressed and upregulated in cells undergoing apoptosis, translocating rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure with two mobile alpha-helices at the N-terminal and a flexible unstructured C-terminal region. Charged residues are crucial for apoptosis promotion and protein translocation. PDCD5 can enhance TAJ/TROY-induced paraptosis-like cell death and acts as a Tip60 co-activator to promote apoptosis. Nucleotide polymorphisms in the 5′-upstream region of PDCD5 affect promoter activity and may influence susceptibility to chronic myelogenous leukemia and lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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