Thermo Fisher Scientific PTGR2 Polyclonal Antibody
Human PTGR2 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며, 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PTGR2. Recombinant protein control fragment (Product #RP-88892). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646112 |
Product Specific Information
Immunogen sequence:
VAGKIGHFLG CSRVVGICGT HEKCILLTSE LGFDAAINYK KDNVAEQLRE SCPAGVDVYF DNVGGNISDT VISQMNENSH IILCGQISQY NKDVPYPPPL SPAIEAIQKE RNITRERFLV LNYKDKFEPG ILQLSQWFKE
Highest antigen sequence identity to the following orthologs:
- Mouse: 86%
- Rat: 87%
Target Information
ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2, or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein belonging to the NADP-dependent oxidoreductase L4BD family.
It functions as a 15-oxoprostaglandin 13-reductase, catalyzing the conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2 in a NADPH-dependent manner.
ZADH1 overexpression represses PPAR gamma transcriptional activity and adipocyte differentiation. It is widely expressed, with highest levels in heart, kidney, liver, pancreas, and prostate, and moderate levels in brain, small intestine, lung, testis, and skeletal muscle.
ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms encoded by a gene located on human chromosome 14q24.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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