Thermo Fisher Scientific XPG Monoclonal Antibody (8H7)
Thermo Fisher Scientific의 XPG Monoclonal Antibody (8H7)는 인간 XPG 단백질을 인식하는 마우스 IgG2a 항체로, WB, ICC/IF, IP 등에 사용 가능. 고순도 Protein A 정제, 액상 형태로 제공되며 DNA 손상 복구 연구에 적합. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:625–1:1250
- View 3 publications
Immunocytochemistry (ICC/IF)
- Tested Dilution: —
- View 5 publications
Immunoprecipitation (IP)
- Tested Dilution: 2 µg/mg protein lysate
- View publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8H7 |
| Immunogen | Recombinant human XPG (Xeroderma Pigmentosum type G) protein, expressed in baculovirus |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2098158 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is essential for DNA repair of solar UV-induced damages.
Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA and cleaves model DNA bubble structures near the junction of unpaired DNA with a duplex region.
A 29-amino acid region of human XPG (residues 981–1009) contains PCNA binding activity, and Arg992 is crucial for this interaction. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, XPA and XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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