Thermo Fisher Scientific XPG Monoclonal Antibody (8H7)

Applications

Western Blot (WB)

• Tested Dilution: 1:625–1:1250
• View 3 publications

Immunocytochemistry (ICC/IF)

• Tested Dilution: —
• View 5 publications

Immunoprecipitation (IP)

• Tested Dilution: 2 µg/mg protein lysate
• View publications

Product Specifications

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is essential for DNA repair of solar UV-induced damages.
Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA and cleaves model DNA bubble structures near the junction of unpaired DNA with a duplex region.
A 29-amino acid region of human XPG (residues 981–1009) contains PCNA binding activity, and Arg992 is crucial for this interaction. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, XPA and XPG.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.