Thermo Fisher Scientific PEN2 Recombinant Rabbit Monoclonal Antibody (JE41-28)
PEN2 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow Cytometry에 적합합니다. HEK293 세포에서 발현되었으며, Protein A로 정제된 액상 형태입니다. 알츠하이머 관련 연구 및 Notch 신호전달 연구에 유용합니다.
- 카탈로그번호
- MA534830
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE41-28 |
| Immunogen | Recombinant protein within Human PEN2 (aa 1–101) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848738 |
Product Specific Information
Positive Control: Mouse spleen tissue, rat cerebellum tissue, human tonsil tissue, human lung cancer tissue, human kidney tissue, mouse testis tissue, A549, SH-SY-5Y.
Target Information
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein.
Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer’s disease.
This gene encodes a protein that is required for Notch pathway signaling and for the activity and accumulation of gamma-secretase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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