Thermo Fisher Scientific CD8 Monoclonal Antibody (3B5), Qdot 605

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: -
• Publications: View 1 publication

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent
• Publications: View 16 publications

Miscellaneous PubMed (Misc)

• Tested Dilution: -
• Publications: View 1 publication

Product Specifications

Additional Formats Available

• Unconjugated
• Alexa Fluor 405
• Alexa Fluor 647
• Alexa Fluor 700
• APC
• APC-Alexa Fluor 750
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Alexa Fluor 610
• PE-Cyanine5.5
• PE-Cyanine7
• PE-Texas Red
• PerCP
• Qdot 655
• Qdot 705
• Qdot 800
• TRI-COLOR
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules.
It is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Binding of MHC-I/peptide complexes triggers activation via Lck kinase, leading to cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs play a key role in pathogen and tumor cell clearance. Differentiation of naïve CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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