Thermo Fisher Scientific CD8 Monoclonal Antibody (3B5), Qdot 605
CD8 항원을 인식하는 Mouse IgG2a 단클론 항체로 Qdot 605 형광체가 결합된 제품입니다. 인간 및 원숭이 시료에 반응하며 Flow Cytometry와 면역세포 분석에 적합합니다. 고순도 정제된 액상 형태로 4°C 보관이 필요합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: -
- Publications: View 1 publication
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
- Publications: View 16 publications
Miscellaneous PubMed (Misc)
- Tested Dilution: -
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Rhesus monkey |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B5 |
| Immunogen | Recognizes the CD8 antigen |
| Conjugate | Qdot™ 605 |
| Excitation / Emission Max | 300 / 603 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | 0.05M borate, pH 8.3, with 1M betaine |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2556437 |
Additional Formats Available
- Unconjugated
- Alexa Fluor 405
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- APC-Alexa Fluor 750
- FITC
- Pacific Blue
- Pacific Orange
- PE
- PE-Alexa Fluor 610
- PE-Cyanine5.5
- PE-Cyanine7
- PE-Texas Red
- PerCP
- Qdot 655
- Qdot 705
- Qdot 800
- TRI-COLOR
- Request custom conjugation
Target Information
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules.
It is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Binding of MHC-I/peptide complexes triggers activation via Lck kinase, leading to cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs play a key role in pathogen and tumor cell clearance. Differentiation of naïve CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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