Thermo Fisher Scientific WDYHV1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000
• Tested in direct-ELISA

Publications

• [References not provided]

Product Specifications

Product Specific Information

This antibody has been tested in direct-ELISA.

Target Information

WDYHV1 mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in the N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination, and degradation as specified by the N-end rule.
It does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. The enzyme does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence activity. In contrast, a proline at position 2 virtually abolishes deamidation of N-terminal glutamine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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