Thermo Fisher Scientific PXR Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human PXR. Recombinant protein control fragment (Product #RP-105811). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PXR,uniProtId:O75469-1,ncbiNodeId:9606,antigenRange:140-277,antigenLength:434,antigenImageFileName:PA5-110975_PXR_O75469-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110975_PXR_O75469-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2856386

Product Specific Information

Immunogen sequence: VQGLTEEQRM MIRELMDAQM KTFDTTFSHF KNFRLPGVLS SGCELPESLQ APSREEAAKW SQVRKDLCSL KVSLQLRGED GSVWNYKPPA DSGGKEIFSL LPHMADMSTY MFKGIISFAK VISYFRDLPI EDQISLLK

Target Information

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.