Thermo Fisher Scientific CARD10 Polyclonal Antibody
Rabbit polyclonal antibody against human CARD10 protein. Unconjugated and supplied in liquid form at 0.10 mg/mL. Suitable for research use in NF-κB signaling and apoptosis studies. Store at 4°C short term or -20°C long term.
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Thermo Fisher Scientific CARD10 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CARD10 (UniProt ID: Q9BWT7-1, Antigen Range: 870–958) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856387 |
Product Specific Information
Immunogen sequence:
RLDFQVCPAE SLSGEELCPS SAPGAPKAQP ATPGLGSRIR AIQESVGKKH CLLELGARGV RELVQNEIYP IVIHVEVTEK NVREVRGLL
Target Information
CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that function as molecular scaffolds, assisting assembly of signal transduction molecules.
CARMA1, CARMA2, and CARMA3 share high sequence and functional homology, but their tissue-specific distribution suggests distinct biological roles.
The CARD domain of CARMA3 interacts specifically with BCL10, a positive regulator of cell apoptosis and NF-κB activation.
CARMA3 is required for EGF-induced NF-κB activation and contributes to tumor growth in vivo, suggesting its potential as a therapeutic target in EGFR-driven tumors.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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