Thermo Fisher Scientific PTGR2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Target Information

ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2, or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein belonging to the NADP-dependent oxidoreductase L4BD family.

• Functions as a 15-oxoprostaglandin 13-reductase, catalyzing the conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2 in a NADPH-dependent manner.
• Overexpression represses PPAR gamma transcriptional activity and adipocyte differentiation.
• Widely expressed in heart, kidney, liver, pancreas, and prostate; moderate levels in brain, small intestine, lung, testis, and skeletal muscle.
• Exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms encoded by a gene located on human chromosome 14q24.3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.