Thermo Fisher Scientific IRAK1 Recombinant Rabbit Monoclonal Antibody (19H32L12)
IRAK1 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, ChIP 등 다양한 응용에 적합. 인간 및 마우스 반응성, 높은 특이성과 재현성 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| ChIP assay (ChIP) | 1 µL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 19H32L12 |
| Immunogen | A peptide corresponding to amino acids 579–591 of human IRAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532270 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generates a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Upon TLR activation, IRAK1 is recruited by MYD88 to the receptor-signaling complex, where it is phosphorylated by IRAK4 and subsequently autophosphorylated and activated.
IRAK1 can phosphorylate TIRAP to promote its ubiquitination and degradation. It also phosphorylates interferon regulatory factor 7 (IRF7), leading to its activation and nuclear translocation, which induces transcription of type I IFN genes and establishes an antiviral state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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