Thermo Fisher Scientific CRACC Monoclonal Antibody (235614)
인간 CRACC(SLAMF7)을 인식하는 Mouse IgG2a 단일클론 항체. Flow Cytometry에 사용 가능하며, 단백질 A/G로 정제된 동결건조 형태. PBS와 5% 트레할로스 완충액에 용해하며, -20°C에서 보관. 연구용 전용 제품.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 2.5 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 235614 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human CRACC/SLAMF7 (Lys27–Ser225) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2577092 |
Product Specific Information
- In direct ELISAs, no cross-reactivity with recombinant human NTB-AR is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent, ERK-mediated pathway and may play a role in lymphocyte adhesion. Isoform 3 does not mediate activation.
SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).
SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea. Expression is detected in NK cells, activated B-cells, and NK-cell lines, but not in promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at a much lower level than isoform 1. Three isoforms are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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