Thermo Fisher Scientific CLU Monoclonal Antibody (OTI2A7), TrueMAB
Human CLU 단백질(아포리포프로테인 J)을 인식하는 Mouse monoclonal antibody. Western blot에 최적화된 TrueMAB 형식. 액상형, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보존. 연구용으로만 사용 가능.
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- TA808578
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 23–227 of human CLU produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of blood plasma proteins. It inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro). Does not require ATP and maintains partially unfolded proteins for subsequent refolding by other chaperones such as HSPA8/HSC70. Secreted isoform 1 protects cells against apoptosis and complement-mediated cytolysis. Intracellular isoforms interact with ubiquitin and SCF E3 ubiquitin-protein ligase complexes, promoting proteasomal degradation of target proteins and modulating NF-κB activity. Nuclear isoforms promote apoptosis, while mitochondrial isoforms inhibit BAX-dependent cytochrome c release, thus suppressing apoptosis. Plays a role in cell proliferation regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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