Thermo Fisher Scientific EGLN2 Monoclonal Antibody (OTI7H3), TrueMAB
EGLN2 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P)에서 검증됨. 인간 시료 반응성. 액상 형태로 제공되며, -20°C에서 보관. 세포 내 산소 항상성 연구 및 HIF 경로 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7H3 |
| Immunogen | Full length human recombinant protein of human EGLN2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Prolyl hydroxylase domain proteins HIF PHD1, HIF PHD2, and HIF PHD3 (known as PHD1, PHD2, and PHD3 in rodents, respectively) hydroxylate HIF-alpha subunits. Hypoxia-inducible factor (HIF) is a transcriptional regulator involved in oxygen homeostasis. These prolyl hydroxylases catalyze the posttranslational formation of 4-hydroxyproline in HIF-alpha proteins.
HIF PHD1 is widely expressed, with the highest expression in testis, and functions as a cellular oxygen sensor important for cell growth regulation. It can localize to the nucleus or cytoplasm and is detected in hormone-responsive tissues such as normal and cancerous mammary, ovarian, and prostate epithelium. HIF PHD1 is encoded by EGLN2, which maps to chromosome 19q13.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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