Thermo Fisher Scientific LXR alpha Recombinant Rabbit Monoclonal Antibody (7Z4H10)
LXR alpha 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot, IHC, ICC, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며 핵 내 발현 단백질 검출에 유용합니다. 고순도 친화 크로마토그래피 정제 및 안정한 PBS 버퍼 포뮬레이션.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7Z4H10 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human LXR alpha (Q13133) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911983 |
Product Specific Information
- Positive test controls: 293T, HepG2, Mouse liver, Mouse kidney, Mouse stomach, Rat liver
- Subcellular location: Nucleus
Immunogen sequence:
MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV
Target Information
Gene: NR1H3 (LXR-alpha, oxysterols receptor)
NR1H3 is a nuclear receptor involved in ligand-dependent transcriptional activation. It interacts with RXR to mediate retinoid responses via LXREs (DR4-type response elements). NR1H3 plays a crucial role in cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also cooperates with RORA in controlling genes involved in hepatic metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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