Thermo Fisher Scientific NPRL2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Immunogen sequence:
  MGSGCRIECI FFSEFHPTLG PKITYQVPED FISRELFDTV QVYIITKPEL
• For short-term use: store at 2–8°C up to 1 week
• For long-term storage: store at -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Zebrafish — 100%

Target Information

NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein containing a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver, and pancreas, with lower expression in lung, kidney, placenta, and heart. NPRL2 is expressed in most lung cancer cell lines and may be involved in tumor suppression. It may play roles in mismatch repair, cell cycle checkpoint signaling, and activation of apoptotic pathways. NPRL2 may enhance the therapeutic efficacy of chemotherapy drugs such as cisplatin by resensitizing resistant patients. The gene encoding NPRL2 is conserved between species and expressed as two isoforms due to alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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