Thermo Fisher Scientific ZCCHC3 Polyclonal Antibody
인간 ZCCHC3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot에 적합하며, DNA 및 RNA 바이러스 면역반응 연구에 활용됩니다. 합성 펩타이드 면역원 기반, 액상 형태로 제공되며 -20°C에서 장기 보관 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human ZCCHC3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2884451 |
Product Specific Information
- Immunogen sequence:
RDFVVGALIL RSIGMDPSDI YAVIQIPGSR EFDVSFRSAE KLALFLRVYE - Short-term storage: 2–8°C up to 1 week
- Long-term storage: -20°C in small aliquots to prevent freeze-thaw cycles
- Predicted homology: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat — 100%
Target Information
ZCCHC3 is a nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses.
It binds DNA and RNA in the cytoplasm and promotes recognition of viral nucleic acids by sensors such as DDX58/RIG-I, IFIH1/MDA5, and CGAS.
Acts as a co-sensor for dsDNA recognition by cGAS, enhancing CGAS oligomerization and activation.
Also facilitates sensing of viral RNA by RIG-I-like receptors via dsRNA binding and promoting Lys-63-linked ubiquitination and activation of DDX58/RIG-I and IFIH1/MDA5.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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