Thermo Fisher Scientific Kir3.4 (KCNJ5) Polyclonal Antibody
Thermo Fisher Scientific의 Kir3.4 (KCNJ5) 폴리클로날 항체는 Human 시료에 반응하며 WB 및 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제된 Rabbit IgG로, 고순도 액상 형태입니다. 신경계 관련 K+ 채널 연구용으로 사용되며, 연구 전용 제품입니다.
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Thermo Fisher Scientific Kir3.4 (KCNJ5) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KCNJ5. Recombinant protein control fragment (Product #RP-90943) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642937 |
Product Specific Information
Immunogen sequence:
VTPWDPKKIP KQARDYVPIA TDRTRLLAEG KKPRQRYMEK SGKCNVHHGN VQETY
Highest antigen sequence identity to orthologs:
- Mouse: 89%
- Rat: 89%
Target Information
G protein-coupled inwardly rectifying potassium channels (Kir3.1 through Kir3.4) are associated with various neurotransmitter receptors in the brain and are highly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex, and thalamus.
Also known as GIRK, Kir3 potassium channels localize to soma, dendrites, and axons of neurons.
Liberated Gβγ subunits from G protein heterotrimers regulate Kir3 channel activity.
- Gβ3- and Gβ4-containing dimers activate Kir3 channels and increase K⁺ current.
- Gβ5-containing dimers inhibit Kir3 K⁺ current.
Kir3 activity is inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which phosphorylates Kir3 tyrosine residues, inactivating the channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-53594_Kir3.4_KCNJ5_P48544-1_Rabbit.svg, PA5-53594_Kir3.4_KCNJ5_P48544-1_Rabbit_PDP.jpeg)
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