Thermo Fisher Scientific Phospho-MAP4K1 (Ser171) Polyclonal Antibody
MAP4K1(Ser171) 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human MAP4K1 around the phosphorylation site of Ser171 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAP4K1 (also known as HPK1, Hematopoietic progenitor kinase 1) is a hematopoietic cell-restricted serine/threonine kinase belonging to the Ste20 kinase family. It acts as an upstream activator of the MEKK/JNK/SAPK signaling pathway, regulating T cell receptor (TCR) signaling and T cell proliferation through phosphorylation of the adaptor protein SLP-76. JNK/SAPK kinases are crucial for stress responses in mammalian cells. MAP4K1 is predominantly expressed in hematopoietic cells, including early progenitors, and specifically activates JNK1, enhancing AP-1-mediated transcription. Unlike PAK65, HPK1 lacks the Rac1/Cdc42-binding domain, indicating a distinct regulatory mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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