Thermo Fisher Scientific Phospho-KIF1B (Ser1057) Polyclonal Antibody
KIF1B 단백질의 Ser1057 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 IHC(Paraffin)에 적합. 사람, 마우스, 랫트 반응성. 고순도, 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-KIF1B (Ser1057) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KIF1B (Accession O60333), corresponding to amino acid residues around phosphorylated Ser1057 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816831 |
Product Specific Information
This antibody detects endogenous levels of KIF1B only when phosphorylated at Ser1057.
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins responsible for distributing organelles, vesicles, and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis.
KIF1B, a member of the KIF1/Unc104 family, is involved in the transport of mitochondria or synaptic vesicles in axons. It is an amino-terminal-type motor protein ubiquitously expressed, with the highest levels in differentiated nerve cells.
The human KIF1B gene maps to chromosome 1p36.2. Mutations in this gene can cause peripheral neuropathy due to defects in axonal transport. The mouse KIF1B gene produces two isoforms via alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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