Thermo Fisher Scientific TRPM4 Monoclonal Antibody (OTI14F1), TrueMAB
TRPM4 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 IHC(P)에서 사용 가능. Human 시료에 반응하며, 액상 형태로 제공. Affinity chromatography로 정제되어 높은 특이성과 재현성을 보장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI14F1 |
| Immunogen | Full-length protein expressed in 293T cells transfected with human TRPM4 expression vector |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. Although activated by increased intracellular Ca²⁺, it is impermeable to it. Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization. Plays a central role in cardiomyocytes, neurons (entorhinal cortex, dorsal root, vomeronasal), endocrine pancreas cells, kidney epithelial cells, and cochlear hair cells. Participates in T-cell activation by modulating Ca²⁺ oscillations after activation, required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells. May contribute to pacemaking or irregular electrical activity under Ca²⁺ overload. Affects Th1 and Th2 cell motility and cytokine production through calcium signaling and NFATC1 localization. Enhances cell proliferation via up-regulation of the beta-catenin signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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