Thermo Fisher Scientific Phospho-PRAS40 (Thr246) Polyclonal Antibody
PRAS40 단백질의 Thr246 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human PRAS40 around the phosphorylation site of Thr246 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Akt signaling pathway contributes to the regulation of apoptosis following various cell death signals. AKT1S1 (also known as PRAS40) is a proline-rich substrate of the kinase AKT1 and is implicated in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. It is also a substrate and potential regulator of mTOR, a serine/threonine kinase that controls cell growth and the cell cycle, and acts as a negative regulator of autophagy. Treatment with insulin-like growth factor-1 (IGF1) can induce phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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