Thermo Fisher Scientific KCNK18 (extracellular) Polyclonal Antibody
KCNK18 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. Lyophilized 형태로 제공되며 -20°C 보관. TRESK 채널 연구 및 면역 기능 관련 연구에 적합.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (IHC) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide (C)EAEENPELKKFLDD, corresponding to amino acid residues 62–75 of mouse K2P 18.1 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736001 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.
Target Information
TRESK (TWIK-related spinal cord K⁺ channel) is a two-pore domain K⁺ channel that induces outward rectification and functions as a background K⁺ channel abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes.
TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine.
It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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